Areas of scientific interest
The main research topics in the field are: (1) separation, purifying, and analysis of bioactive compounds such as flavonoids, flavonolignans, essential oils, fatty acids and their glycerides; (2) enzymatic synthesis of new antioxidants/flavonoids-fatty acid bioconjugates, separation and analysis; (3) evaluation of the natural compounds and bioconjugates for their possible biological activity and “dual bioactivity”, respectively. These topics were developed within the national programs PN2 62072 / 2008-2011 and CEEX P-CD-18 / 2005-2007 (both as partner responsible) on Hepatoprotecting nanoparticles with enhanced bioavailability (Nano-HEPAT) and Nanocomposites / nanocrystals with applications in biotechnology, agriculture, food, health, and environmental protection fields (NUSA), respectively.
The research in supramolecular chemistry field was especially focused on cyclodextrin-based nanoparticles for methods of synthesis, analysis, water behaviour and release mechanisms of flavonoids, flavonolignans, triterpenoids and their fatty acid bioconjugates, essential oils, berberine, chelidonine, nicotine / cyclodextrin complexes, as well as synthesis and analysis of liposomes containing magnetic nanoparticles. These findings were implemented by PN2 41070 / 2007-2010 grant (partner responsible), as well as PN2 62072 / 2008-2011, CEEX P-CD-18 / 2005-2007, and CNCSIS AT 25, Grant No 32940 / 2004-2005 (project leader). All these studies were continued in partnerships with teams from Germany (University of Hohenheim), France (Université du Littoral Cőte d’Opale) and Turkey (Akdeniz University).
Cyclodextrin-based supramolecular systems containing flavonoids, flavonolignans, their fatty acid bioconjugates, essential oil components, alkaloids, fatty acid and their glycerides were subjected to theoretical studies involving molecular modeling, docking, quantitative structure-activity/property relationships and biological activity prediction methods. Moreover, I was involved in VHTS studies in collaboration with University of New Mexico School of Medicine, Albuquerque, USA.
Relevant publications (* as main author):
Polytechnic University of Timişoara, Faculty of Industrial Chemistry and Environmental Engineering, Department of Applied Chemistry, Organic and Natural Compounds Engineering, 300006 – Timişoara, Victory Sq. 2, Romania
OncoGen Centre – SCJUPB Timişoara